2-Chloro-5-chloromethylthiazole
Light yellow crystal or light yellow liquid , content: ≥98%, melting point: 29-31 ℃.
Essential intermediate for the synthesis of second-generation neonicotinoid insecticides such as thiamethoxam, thiamethoxam, and clothianidin.
2-Chloro-5-Chloromethylthiazole is an essential intermediate in the production of agrochemicals, pharmaceuticals, and specialty chemicals. Its thiazole-based structure provides versatility in chemical synthesis, making it a valuable component in various industrial applications.
Chemical Characteristics
| Melting point | 31 |
| Boiling point | 268.6±32.0 °C(Predicted) |
| density | 1.503±0.06 g/cm3(Predicted) |
| refractive index | n20/D1.571 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | soluble in Methanol |
| pka | 0.19±0.10(Predicted) |
| color | White to Light yellow |
| BRN | 5861439 |
| InChI | InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2 |
| InChIKey | VRMUIVKEHJSADG-UHFFFAOYSA-N |
| SMILES | S1C(CCl)=CN=C1Cl |
| CAS DataBase Reference | 105827-91-6(CAS DataBase Reference) |
Applications
Agrochemical Synthesis:
Used as a key intermediate in the production of insecticides, herbicides, and fungicides.
Integral in the synthesis of neonicotinoid insecticides.
Pharmaceutical Manufacturing:
Serves as a building block in creating pharmaceutical compounds.
Facilitates the development of active ingredients with diverse biological properties.
Specialty Chemicals:
Applied in the synthesis of advanced materials and performance chemicals.
Research and Development:
A versatile reagent for laboratory-scale chemical synthesis.
Advantages
High chemical reactivity suitable for a variety of synthesis pathways.
High purity (≥98%) ensures consistent performance in industrial and laboratory applications.
Compatible with numerous organic solvents for ease of handling.
Safety and Handling
Protective Measures:
Use appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats.
Ensure proper ventilation or use a fume hood during handling.
Storage:
Store in a cool, dry place, away from direct sunlight and heat sources.
Keep the container tightly sealed to prevent moisture absorption.
Hazards:
Inhalation: May cause respiratory irritation.
Skin Contact: Can cause irritation or sensitization.
Eye Contact: Risk of severe irritation.
Ingestion: Harmful if swallowed.
First Aid Measures:
Inhalation: Move to fresh air and seek medical attention if symptoms persist.
Skin Contact: Wash thoroughly with soap and water.
Eye Contact: Rinse with water for at least 15 minutes and consult a doctor.
Ingestion: Do not induce vomiting; seek immediate medical attention.
Conclusion
2-Chloro-5-Chloromethylthiazole is a versatile intermediate widely used in the agrochemical and pharmaceutical industries. Its high reactivity and stability make it a reliable choice for advanced chemical synthesis. Proper handling and storage are essential to maintain its integrity and ensure safe use.
FAQ
1. What is the primary use of 2-Chloro-5-Chloromethylthiazole?
It is primarily used as an intermediate in the synthesis of agrochemicals and pharmaceuticals.
2. Is it water-soluble?
It is slightly soluble in water but more soluble in organic solvents.
3. What precautions are necessary when handling this compound?
Use appropriate PPE, ensure good ventilation, and avoid direct contact with the skin or eyes.
4. Can it be stored long-term?
Yes, provided it is stored in a cool, dry place away from heat and moisture.
5. Is it hazardous?
Yes, it may cause irritation or harm upon contact, inhalation, or ingestion. Handle with care.
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