3,4-Xylidine
Pure product is flaky or columnar crystal, m.p. 49-51°C, b.p. 226°C, relative density 1.076, f.p. 98°C, easily soluble in petroleum ether, slightly soluble in water.
3,4-Xylidine is an intermediate in the herbicide pendimethalin and also an intermediate in the pharmaceutical vitamin B2.
3,4-Xylidine is an aromatic amine used as a chemical intermediate in various industrial applications, including the synthesis of dyes, agrochemicals, and pharmaceuticals. Its structure, containing two methyl groups on the benzene ring, imparts unique chemical properties.
Chemical Characteristics
| Melting point | 49-51 °C(lit.) |
| Boiling point | 226 °C(lit.) |
| density | 1.076 |
| vapor pressure | 3.72Pa at 25℃ |
| refractive index | 1.5135 (estimate) |
| Fp | 209 °F |
| storage temp. | Store below +30°C. |
| solubility | methanol: 0.1 g/mL, clear |
| pka | pK1:5.17(+1) (25°C) |
| form | Crystalline Mass or Crystals |
| color | Light beige to pink to brown |
| Water Solubility | <1 g/L (24 ºC) |
| Merck | 14,10084 |
| BRN | 507414 |
| LogP | 1.8 at 25℃ |
| Dissociation constant | 5.15 at 25℃ |
| CAS DataBase Reference | 95-64-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenamine, 3,4-dimethyl-(95-64-7) |
| EPA Substance Registry System | 3,4-Dimethylaniline (95-64-7) |
Applications
Dye Manufacturing:
A precursor in the production of azo dyes and other colorants.
Contributes to vibrant and durable dye formulations.
Agrochemical Synthesis:
Used in the manufacture of herbicides, fungicides, and pesticides.
Pharmaceutical Industry:
Serves as an intermediate in synthesizing active pharmaceutical ingredients (APIs).
Specialty Chemicals:
Utilized in the production of fine chemicals, resins, and polymers.
Plays a role in performance-enhancing additives.
Advantages
High reactivity for efficient synthesis.
Versatility in applications across multiple industries.
Stable and easy to handle under proper conditions.
Safety and Handling
Protective Measures:
Wear gloves, goggles, and protective clothing during handling.
Ensure adequate ventilation or use a fume hood.
Storage:
Store in a cool, dry, and well-ventilated area.
Keep away from oxidizing agents and direct sunlight.
Ensure the container is tightly closed to prevent contamination.
Hazards:
Inhalation: Can irritate the respiratory tract.
Skin Contact: May cause irritation or allergic reactions.
Eye Contact: Risk of severe irritation.
Ingestion: Harmful if swallowed; can cause systemic toxicity.
First Aid Measures:
Inhalation: Move to fresh air; seek medical attention if symptoms persist.
Skin Contact: Wash with soap and water thoroughly.
Eye Contact: Rinse with plenty of water for at least 15 minutes; consult a doctor.
Ingestion: Do not induce vomiting; seek immediate medical attention.
Conclusion
3,4-Xylidine is a versatile intermediate widely used in the production of dyes, agrochemicals, and pharmaceuticals. Its unique chemical properties and stability make it a valuable choice for industrial applications. Proper handling and storage are essential to ensure safety and maintain product integrity.
FAQ
1. What is the primary use of 3,4-Xylidine?
It is primarily used as an intermediate in the production of dyes, agrochemicals, and pharmaceuticals.
2. Is it water-soluble?
It is slightly soluble in water but highly soluble in organic solvents.
3. How should it be stored?
Store in a cool, dry, and well-ventilated area, away from oxidizing agents and direct sunlight.
4. Is it hazardous?
Yes, it can cause irritation or harm upon contact, inhalation, or ingestion. Handle with care.
5. Does it oxidize?
Yes, it may oxidize upon prolonged exposure to air, leading to discoloration.
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