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Benzyltriethylammonium chloride

Cas No. 56-37-1
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Detail

This product is white solid. Melting point 155 ℃ (decomposition).


Used as pharmaceutical intermediate and phase transfer catalyst


Introduction

Benzyltriethylammonium chloride (BTEAC) is a quaternary ammonium salt commonly used as a phase-transfer catalyst in organic synthesis. It enhances the reaction rates between reactants in different phases, such as water and organic solvents.


Chemical Characteristics

Melting point 190-192 °C (dec.) (lit.)
Boiling point 366.11°C (rough estimate)
density 1.08 g/mL at 25 °C
refractive index n20/D 1.479
Fp >100°C
storage temp. Store below +30°C.
solubility H2O: 0.1 g/mL, clear
form Liquid
color White to beige
PH6-8 (100g/l, H2O, 20℃)
PH Range6 - 8
Water Solubility 700 g/L (20 ºC)
Sensitive Hygroscopic
Decomposition 185°C
BRN 3574984
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyHTZCNXWZYVXIMZ-UHFFFAOYSA-M
CAS DataBase Reference56-37-1(CAS DataBase Reference)
EPA Substance Registry SystemBenzyltriethylammonium chloride (56-37-1)



Applications

  1. Organic Synthesis

    • Used as a phase-transfer catalyst in nucleophilic substitution, alkylation, and oxidation reactions.

    • Facilitates the formation of C-C and C-N bonds.

  2. Polymer Chemistry

    • Employed in the preparation of polymers by catalyzing polymerization reactions.

  3. Pharmaceutical Industry

    • Assists in the synthesis of active pharmaceutical ingredients (APIs).

  4. Chemical Industry

    • Applied in the production of fine chemicals and specialty compounds.

  5. Electroplating

    • Serves as an additive in electroplating solutions to improve plating quality.


Handling and Storage

  • Storage Conditions: Store in a tightly closed container in a dry, well-ventilated area away from incompatible materials.

  • Safety Precautions:

    • Use personal protective equipment (PPE) to prevent inhalation, ingestion, or skin contact.

    • Avoid exposure to heat or moisture to maintain product stability.



FAQs

1. What is the role of benzyltriethylammonium chloride in phase-transfer catalysis?
It facilitates the transfer of ionic reactants between immiscible phases, enabling reactions that would otherwise be slow or impossible.

2. Is benzyltriethylammonium chloride hazardous?
It may cause irritation to the skin, eyes, and respiratory tract. Handle with care and follow safety guidelines.

3. Can it be used in aqueous systems?
Yes, BTEAC is soluble in water and is effective in reactions involving aqueous and organic phases.

4. What are common alternatives to BTEAC?
Other quaternary ammonium salts like tetrabutylammonium bromide (TBAB) or benzyltrimethylammonium chloride may be used as alternatives.


For further technical details or specific applications, consult the product’s technical data sheet (TDS) or material safety data sheet (MSDS).


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