Dichloroacetic acid
Colorless liquid. Soluble in water, ethanol and ether.
Used in organic synthesis, pharmaceutical industry , dye intermediates, etc
Introduction
Dichloroacetic acid (DCA) is a chlorinated carboxylic acid widely used in chemical synthesis and industrial applications. Its reactivity and acidity make it a valuable intermediate in the production of various organic compounds.
Chemical Characteristics
| Melting point | 9-11 °C(lit.) |
| Boiling point | 194 °C(lit.) |
| density | 1.56 g/mL at 25 °C (lit.) |
| vapor density | 4.5 (vs air) |
| vapor pressure | 0.19 mm Hg ( 20 °C) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 1.48(at 25℃) |
| form | Liquid |
| color | APHA: <50 |
| PH | 1.2 (129g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,3050 |
| BRN | 1098596 |
| Dielectric constant | 10.7（-7℃） |
| Exposure limits | ACGIH: TWA 0.5 ppm (Skin) |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. Reacts with water. Protect from moisture. Hygroscopic. |
| InChIKey | JXTHNDFMNIQAHM-UHFFFAOYSA-N |
| LogP | 0.92 |
| CAS DataBase Reference | 79-43-6(CAS DataBase Reference) |
| IARC | 2B (Vol. 63, 84, 106) 2014 |
| NIST Chemistry Reference | Acetic acid, dichloro-(79-43-6) |
| EPA Substance Registry System | Dichloroacetic acid (79-43-6) |
Applications
Chemical Synthesis
Used as an intermediate in the synthesis of pharmaceuticals, herbicides, and dyes.
Precursor for the production of other halogenated compounds.
Analytical Chemistry
Serves as a reagent for various laboratory analyses.
Medical Research
Investigated for potential therapeutic uses, particularly in metabolic disorders and cancer research.
Industrial Uses
Employed in the formulation of cleaning agents and as a solvent in specialized processes.
Handling and Storage
Storage Conditions:
Store in a tightly sealed container in a cool, dry, and well-ventilated area. Keep away from heat, moisture, and incompatible materials such as bases and strong oxidizing agents.Safety Precautions:
Corrosive: Avoid contact with skin, eyes, and clothing.
Inhalation Risk: Use in well-ventilated areas to minimize exposure to vapors.
PPE: Always wear gloves, safety goggles, and protective clothing when handling.
FAQs
1. Is dichloroacetic acid environmentally hazardous?
Yes, it can be harmful to aquatic life and should be disposed of in accordance with local environmental regulations.
2. Can DCA be used in aqueous solutions?
Yes, it is highly soluble in water, making it suitable for aqueous applications.
3. What precautions should be taken during transportation?
Ensure containers are secure and labeled appropriately. Follow regulations for transporting corrosive substances.
4. Are there alternatives to dichloroacetic acid for industrial applications?
Depending on the application, other halogenated acids or organic acids may be suitable substitutes.
For detailed information regarding specific applications or safety guidelines, consult the product's technical data sheet (TDS) or safety data sheet (SDS).
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