Glycine ethyl ester hydrochloride

White crystalline powder at room temperature. Easily soluble in water, solubility in water>1000 g/L(20 ºC), slightly soluble in ethanol, insoluble in ether, easy to absorb moisture when placed in the air, slowly decompose when the temperature exceeds 200 ºC.

Glycine ethyl ester hydrochloride is an important intermediate in the preparation of chrysanthemic acid or dichlorochrysanthemic acid, as well as in the fungicide isobutyl urea.

Glycine Ethyl Ester Hydrochloride is a chemical compound that belongs to the class of amino acid derivatives, specifically the ester of glycine. It is commonly used in various chemical, pharmaceutical, and industrial applications. This compound is produced by esterifying glycine, the simplest amino acid, with ethanol, and then adding hydrochloric acid to form its hydrochloride salt.

Applications

Pharmaceutical and Biomedical

• Precursor in Pharmaceutical Synthesis: Glycine ethyl ester hydrochloride is used as an intermediate in the synthesis of various drugs, including those that modulate neurotransmitter activity, as glycine is an important inhibitory neurotransmitter in the central nervous system.

• Amino Acid Supplement: It is sometimes used in the formulation of amino acid supplements for individuals with protein deficiencies or in the treatment of metabolic disorders.

• Glycine Derivatives: Glycine ethyl ester hydrochloride serves as a precursor for the synthesis of other glycine derivatives, which can be used in a variety of therapeutic applications, including muscle relaxation and as a component of intravenous (IV) nutrition solutions.

Industrial and Chemical Synthesis

• Polymer Production: Used in the synthesis of polyesters, particularly those that incorporate amino acid derivatives. These polymers have various industrial applications, such as in coatings and plastic materials.

• Cosmetic Ingredients: Due to its amino acid structure, it may be used in the cosmetic industry for skin care products and as a humectant, helping to maintain moisture in formulations.

Agricultural

• Fungicide and Pesticide Development: Glycine ethyl ester hydrochloride can be involved in the development of specific fungicides and pesticides, primarily by acting as a precursor in the synthesis of biologically active compounds.

Laboratory Reagent

• Biochemical Research: In laboratory settings, it is often used as a reagent in chemical synthesis, particularly in the production of glycine-based derivatives, which can be involved in enzyme studies and protein research.

Mode of Action

As a derivative of glycine, glycine ethyl ester hydrochloride is known for its interaction with certain biological systems. Glycine itself is a crucial inhibitory neurotransmitter in the brain and spinal cord, and its derivatives can be used to modulate the activity of neural receptors. In pharmaceutical formulations, glycine derivatives like this compound may act to relax muscles or assist in various metabolic processes.

Advantages

1. Versatility: Its chemical structure makes it versatile for use in a wide range of applications from pharmaceutical development to industrial synthesis.

2. Hydrophilic Nature: Its water solubility makes it easy to incorporate into various formulations, including aqueous-based systems.

3. Precursor for Complex Compounds: Used as a building block for more complex compounds, it is an important intermediate in drug and chemical synthesis.

4. Biological Activity: As an amino acid derivative, it has potential uses in biochemistry and molecular biology, making it valuable for research.

Safety and Handling

Handling

• Protective Equipment: When handling Glycine Ethyl Ester Hydrochloride, it is recommended to wear gloves, safety goggles, and protective clothing to prevent direct contact.

• Storage: Store in a cool, dry place, away from heat and moisture. Keep containers tightly closed to prevent contamination.

Health Hazards

• Inhalation: Not typically hazardous in normal handling, but inhalation of dust or vapors should be avoided.

• Skin and Eye Contact: May cause mild irritation. If contact occurs, rinse with water for at least 15 minutes.

• Ingestion: Ingestion of large quantities may cause mild gastrointestinal irritation. Seek medical attention if significant exposure occurs.

Conclusion

Glycine Ethyl Ester Hydrochloride is an essential chemical compound with a wide array of applications in pharmaceutical, industrial, and research sectors. Its role as a precursor in drug synthesis, biochemical research, and polymer production makes it an important compound in both the commercial and scientific fields. Its properties, such as solubility and biological activity, contribute to its versatility in various formulations.

FAQ

1. What is Glycine Ethyl Ester Hydrochloride used for?
Glycine Ethyl Ester Hydrochloride is used in pharmaceutical synthesis, as a precursor for glycine derivatives, in cosmetic formulations, and in research related to amino acids and proteins.

2. Is Glycine Ethyl Ester Hydrochloride safe to handle?
Yes, it is generally safe when handled with care. Protective gear should be used to avoid contact with skin and eyes.

3. How is Glycine Ethyl Ester Hydrochloride stored?
It should be stored in a cool, dry place in a tightly sealed container, away from heat, light, and moisture.

4. What industries use Glycine Ethyl Ester Hydrochloride?
It is used in the pharmaceutical industry, cosmetic formulation, chemical manufacturing, and academic research.

5. Can Glycine Ethyl Ester Hydrochloride be used in food products?
It is not commonly used in food applications but may be present in certain medical supplements or IV solutions. Always check for specific regulatory approvals before using it in food products.