How 5-Chloro-2,3-Difluoropyridine (CDFP) Supports Advanced Chemical Synthesis

2025-06-13 09:42

Introduction to 5-Chloro-2,3-Difluoropyridine (CDFP)
5-Chloro-2,3-difluoropyridine (CDFP) is a high-purity chemical intermediate (96%) commonly used in pharmaceutical and agrochemical synthesis. Its unique structure, featuring chlorine and fluorine atoms on a pyridine ring, makes it valuable for creating compounds with improved biological activity, stability, and bioavailability.


Applications in Industry

CDFP is primarily used as a building block in the synthesis of pharmaceuticals, herbicides, and fungicides. Its ability to introduce fluorine atoms improves the efficacy and environmental resistance of agrochemicals. In medicinal chemistry, CDFP derivatives often exhibit enhanced potency and selectivity.


Advantages of Using CDFP

  • High purity (96%) ensures consistent reaction performance.

  • Halogenated pyridine structure provides versatility in chemical transformations.

  • Improves metabolic stability of final products.

  • Facilitates creation of compounds with superior biological properties.


Handling and Safety Considerations
CDFP should be handled with standard industrial safety practices, including use of gloves, goggles, and proper ventilation. Although not highly volatile, exposure to dust or vapors should be minimized. Storage in a cool, dry place away from strong oxidizers is recommended to maintain product integrity.


Quality and Supply
Suppliers typically provide CDFP in powder or liquid form with purity guaranteed at 96%. Quality control measures include purity analysis by HPLC or GC and verification of halogen content. Reliable supply chains ensure consistent availability for large-scale synthesis.


FAQ About 5-Chloro-2,3-Difluoropyridine (CDFP)

Q1: What is the main use of CDFP?
It is mainly used as a chemical intermediate for synthesizing pharmaceuticals and agrochemicals.

Q2: Why are the chlorine and fluorine atoms important?
They enhance the chemical reactivity and improve the metabolic stability and effectiveness of derived compounds.

Q3: How should CDFP be stored?
In a cool, dry place, away from strong oxidizers and moisture to preserve stability.

Q4: Is CDFP hazardous?
It requires careful handling to avoid inhalation or skin contact but is generally stable under proper conditions.

Q5: Can CDFP be customized for different purity levels?
Typically supplied at 96% purity; other purities may be available on special request from manufacturers.

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