What Is Propargyl Chloride 85% in DMF and How Is It Used in Organic Synthesis?

Technical Introduction

Propargyl Chloride (3-chloro-1-propyne) is an alkyne-containing organic halide with the molecular formula C₃H₃Cl.
In this product form, it is supplied as an 85% solution in dimethylformamide (DMF) to improve stability, ease of handling, and reaction compatibility.
Propargyl Chloride is a highly reactive electrophile that participates in nucleophilic substitution and coupling reactions.
Its alkyne triple bond provides versatility in click chemistry, cross-coupling, and cycloaddition reactions.

Applications

1. Pharmaceutical Intermediate

• Used to introduce alkyne functionality into drug molecules.

• Key in synthesizing enzyme inhibitors, antiviral agents, and anticancer compounds.

2. Agrochemical Synthesis

• Starting material for herbicides, fungicides, and insecticidal agents with triple-bond-containing side chains.

3. Polymer & Material Science

• Enables the production of functional polymers via click chemistry.

• Useful in surface modification and crosslinking of resins.

4. Organic Synthesis R&D

• Acts as a building block for heterocycles and ligand frameworks.

Advantages

• High Reactivity: Chlorine atom facilitates nucleophilic substitution.

• Triple Bond Versatility: Compatible with a wide range of organic transformations.

• Pre-dissolved in DMF: Improves handling and solubility in polar aprotic environments.

• Consistent Purity: 85% concentration ensures reproducible reactions.

Typical Parameters

FAQs

Q1: Why is Propargyl Chloride sold in DMF instead of pure form?
A1: Pure Propargyl Chloride is unstable and prone to polymerization; DMF stabilizes it and simplifies handling.

Q2: Is it compatible with aqueous reactions?
A2: Generally, no—it reacts readily with nucleophiles in water, so it’s better used in anhydrous conditions.

Q3: Can it be used in click chemistry?
A3: Yes, the terminal alkyne makes it a useful precursor for azide–alkyne cycloadditions.

Q4: How should it be handled safely?
A4: Use gloves, goggles, and work in a fume hood; it is toxic and lachrymatory.

Q5: What is the main industrial advantage of the 85% DMF form?
A5: It avoids solidification, ensures better dosing accuracy, and extends shelf life.