What Is 3,5,6-Trichloropyridin-2-ol Sodium (NATCP) and How Is It Used in Agrochemical Synthesis?
Technical Introduction
3,5,6-Trichloropyridin-2-ol Sodium (abbreviated as NATCP) is a sodium salt of a chlorinated pyridin-2-ol derivative, with the molecular formula approximately C₅H₂Cl₃NNaO. It appears as a white to off-white powder with a purity of about 87.5%.
NATCP is valued for its role as a key intermediate in the synthesis of various herbicides and pesticides, especially those targeting resistant weed species. The presence of multiple chlorine atoms enhances its chemical reactivity and biological activity.
Applications
1. Agrochemical Intermediate
Used primarily in the production of selective herbicides, including derivatives that inhibit specific plant enzymes.
Key building block in chlorinated pyridine-based pesticides.
2. Chemical Synthesis
Serves as a precursor for various functionalized heterocyclic compounds.
Applicable in specialty chemical manufacturing for modifying electronic and steric properties of molecules.
Advantages
High Reactivity due to multiple chlorine substitutions facilitating further chemical modifications.
Good Purity (87.5%) suitable for industrial-scale synthesis.
Enhanced Herbicidal Activity imparted by the trichlorinated pyridin-2-ol structure.
Stable Sodium Salt Form improves handling and storage properties compared to free acid forms.
Typical Parameters
| Property | Value |
|---|---|
| Chemical Formula | C₅H₂Cl₃NNaO |
| Molecular Weight | Approx. 219.4 g/mol |
| Purity (%) | ≥87.5 |
| Appearance | White to off-white powder |
| CAS Number | 57690-14-7 (approx.) |
| Solubility | Soluble in water and polar solvents |
| Storage | Store in cool, dry, ventilated area |
| Stability | Stable under recommended storage conditions |
| Shelf Life | 24 months (sealed) |
FAQs
Q1: What is the primary use of NATCP?
A1: NATCP is mainly used as an intermediate in the synthesis of chlorinated herbicides and pesticides.
Q2: Is NATCP safe to handle?
A2: It should be handled with care, using personal protective equipment, as it may cause irritation.
Q3: How is NATCP stored to maintain stability?
A3: Keep it sealed in a cool, dry place away from moisture and strong acids or bases.
Q4: Can NATCP be used directly as a pesticide?
A4: No, it is an intermediate and requires further chemical processing before application.
Q5: What advantages does the sodium salt form offer?
A5: Improved solubility and stability compared to the free acid, facilitating industrial processing.
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