What Is 2,6-Xylidine and Why Is It Important in Pharmaceutical and Dye Manufacturing?
Technical Introduction
2,6-Xylidine, also known as 2,6-dimethylaniline, is an aromatic amine with the molecular formula C₈H₁₁N.
It consists of a benzene ring substituted with two methyl groups at the 2- and 6-positions and an amino group at the 1-position.
This structural arrangement gives 2,6-Xylidine distinct chemical reactivity and makes it a crucial intermediate in organic synthesis.
It appears as a colorless to pale yellow liquid with a mild aromatic odor and is soluble in most organic solvents.
Applications
1. Pharmaceutical Industry
Key intermediate in the synthesis of local anesthetics such as lidocaine and related compounds.
Used in producing analgesics and other therapeutic agents.
2. Dye and Pigment Manufacturing
Acts as a building block for azo dyes, giving vibrant and stable color shades.
Used in producing pigments for textiles, plastics, and coatings.
3. Agrochemical Synthesis
Serves as a precursor in herbicide and pesticide manufacturing.
4. Specialty Chemicals
Applied in the production of rubber processing chemicals and polymer additives.
Advantages
High Reactivity: Amino and methyl groups allow versatile chemical transformations.
Proven Track Record: Widely used in pharmaceuticals for decades.
Stable in Storage: Maintains quality under recommended storage conditions.
Multi-Industry Relevance: Serves pharmaceutical, agrochemical, and dye industries alike.
Typical Parameters
| Property | Value |
|---|---|
| Chemical Formula | C₈H₁₁N |
| Molecular Weight | 121.18 g/mol |
| CAS Number | 87-62-7 |
| Appearance | Colorless to pale yellow liquid |
| Purity (%) | ≥99.0 |
| Boiling Point (°C) | ~215–216 |
| Flash Point (°C) | ~90 |
| Solubility | Soluble in organic solvents; low in water |
| Storage | Store in cool, dry, well-ventilated area |
| Shelf Life | 24 months (sealed) |
FAQs
Q1: What is the most common use of 2,6-Xylidine?
A1: As a pharmaceutical intermediate for making lidocaine and related anesthetics.
Q2: Is 2,6-Xylidine hazardous?
A2: Yes, it can be harmful if inhaled or absorbed through skin; proper PPE is essential.
Q3: Can it be transported easily?
A3: Yes, but it must comply with hazardous goods regulations.
Q4: Is it stable in normal storage conditions?
A4: Yes, when kept sealed away from light and moisture.
Q5: Are there alternatives to 2,6-Xylidine in synthesis?
A5: Depending on the application, other substituted anilines may be used, but 2,6-Xylidine offers optimal performance for certain drugs.
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