Hexapeptide-11: A Biofermented Peptide for Skin Rejuvenation and Hair Care

Technical Introduction

Hexapeptide-11 is a synthetic bioactive peptide originally derived through yeast fermentation. With its unique amino acid sequence, it is known to activate transcription factors that regulate genes involved in collagen synthesis, elastin production, and antioxidant defense.

Unlike some synthetic peptides, Hexapeptide-11 is inspired by natural peptides, offering a balance between efficacy and biocompatibility. It plays a role in cellular communication, promoting youthful cellular behavior and protecting against environmental stress.

• INCI Name: Hexapeptide-11

• Chemical Class: Oligopeptide (6 amino acids)

• Origin: Fermentation-derived peptide

• Appearance: White to off-white powder

• Solubility: Water-soluble

• Molecular Weight: ~1,100 Da

• Stability: Stable in aqueous formulations at pH 4.5–7.0

Applications

1. Cosmetics & Skincare

• Anti-aging formulations → Boosts collagen and elastin to firm skin.

• Skin elasticity products → Improves resilience and tone.

• Brightening creams → Supports antioxidant defense and protects against free radicals.

• Anti-pollution skincare → Protects against oxidative stress from UV and environmental aggressors.

• Moisturizing products → Enhances hydration and skin smoothness.

2. Hair Care

• Strengthening shampoos & conditioners → Improves follicle anchoring and reduces breakage.

• Scalp serums → Promotes healthy scalp environment for stronger hair.

• Anti-aging hair tonics → Maintains elasticity of hair fibers.

3. Dermatological & Research Applications

• Studied for gene regulation effects in aging skin cells.

• Potential applications in anti-oxidative and cellular longevity research.

✅ Advantages

• Collagen & elastin stimulation → Improves firmness and elasticity.

• Antioxidant defense → Reduces oxidative stress and photoaging.

• Gene expression modulation → Promotes youthful cellular activity.

• Hair strengthening → Supports healthier, thicker hair.

• Biocompatible → Derived from natural fermentation, safe and well-tolerated.

• Synergistic effects → Works well with niacinamide, hyaluronic acid, and botanical extracts.

⚙️ Technical Specifications (Cosmetic Grade)

⚠️ Safety & Regulatory Notes

• Topical Use: Safe for cosmetic formulations.

• Irritation Potential: Very low; suitable for sensitive skin.

• Global Regulation: Approved in major cosmetic markets (EU, USA, Asia).

• Formulation Tips: Incorporate during cool-down phase (<40 °C) to maintain peptide integrity.

❓ FAQ

Q1: What makes Hexapeptide-11 unique among peptides?
It is fermentation-derived, giving it a natural origin while retaining strong activity in regulating collagen, elastin, and antioxidant-related genes.

Q2: How soon can results be seen in skin care?
Improvements in firmness, elasticity, and brightness are typically observed after 6–8 weeks of continuous use.

Q3: Can it be used in both skin and hair care products?
Yes, it is one of the few peptides with dual benefits for skin rejuvenation and hair strengthening.

Q4: Is Hexapeptide-11 suitable for sensitive skin?
Yes, it is mild and non-irritating, making it suitable for even delicate formulations such as eye creams.

Q5: What types of products use Hexapeptide-11?
Common in anti-aging serums, firming creams, scalp serums, hair-strengthening shampoos, and antioxidant-rich skincare lines.