Acetyl Decapeptide-3: A Biomimetic Growth Factor Peptide for Skin Renewal and Anti-Aging

Technical Introduction

Acetyl Decapeptide-3 is a synthetic decapeptide (10 amino acids) that mimics the activity of growth factors involved in skin regeneration, especially basic fibroblast growth factor (bFGF). It belongs to the class of biomimetic peptides, designed to bind with cell receptors and activate intracellular signaling, thereby stimulating cell proliferation, extracellular matrix production, and tissue repair.

Through its biomimetic action, Acetyl Decapeptide-3 enhances the production of collagen, elastin, and glycosaminoglycans, leading to visible improvements in skin firmness, elasticity, and wrinkle reduction.

• INCI Name: Acetyl Decapeptide-3

• Also Known As: Biomimetic bFGF peptide, CG-Decapeptide-3

• Origin: Synthetic peptide via solid-phase peptide synthesis (SPPS)

• Molecular Weight: ~1,000–1,200 Da

• Appearance: White to off-white powder

• Solubility: Water-soluble

• Stability: Stable in aqueous solutions under recommended conditions

Applications

1. Cosmetics & Skincare

• Anti-aging serums & creams → Reduces wrinkles, fine lines, and sagging.

• Regenerative skincare → Boosts repair in mature and damaged skin.

• Brightening formulas → Encourages renewal for even tone and radiance.

• Post-procedure care → Speeds up skin recovery after laser, microneedling, or peels.

• Hair growth formulations → Stimulates scalp microcirculation and follicle vitality.

2. Medical Aesthetic Use

• Adjunct in mesotherapy → Used in peptide cocktails for skin rejuvenation.

• Support for scar reduction → Helps in reducing hypertrophic scars and stretch marks.

✅ Advantages

• Biomimetic growth factor activity → Safe alternative to recombinant growth factors.

• Stimulates collagen & elastin synthesis → Improves firmness and elasticity.

• Promotes wound healing & regeneration → Supports skin recovery.

• Anti-wrinkle performance → Visibly smooths fine lines and dynamic wrinkles.

• Safe and stable → Lower immunogenic risk compared to natural growth factors.

• Synergistic with other peptides → Works well with Oligopeptide-1 (EGF) and Palmitoyl peptides.

⚙️ Technical Specifications (Cosmetic Grade)

⚠️ Safety & Regulatory Notes

• Topical use only — not for injection.

• Well tolerated — low irritation and sensitization profile.

• Regulatory status — Approved for cosmetic use globally (EU, USA, Asia).

• Formulation tip — Add during cool-down (<40 °C) stage to preserve peptide integrity.

❓ FAQ

Q1: How does Acetyl Decapeptide-3 differ from Oligopeptide-1 (EGF)?
Oligopeptide-1 (EGF) is a growth factor peptide acting directly on EGFR, while Acetyl Decapeptide-3 is a biomimetic peptide that mimics bFGF activity. Both promote regeneration, but through different pathways.

Q2: How soon can results be seen in skincare?
Clinical studies show improvements in skin elasticity and smoothness within 4–6 weeks, with continued benefits over 12 weeks.

Q3: Is it safe for sensitive or post-procedure skin?
Yes, it is well tolerated and frequently recommended in post-laser and post-peel products.

Q4: Can it be combined with retinol or vitamin C?
Yes, it works synergistically — retinol stimulates cell turnover, while Acetyl Decapeptide-3 boosts regeneration.

Q5: Is it effective in haircare?
Yes, it helps stimulate follicle vitality and is often used in anti-hair loss serums.