1,3-Cyclohexanedione (1,3-CHD): A Versatile Intermediate in Chemical Synthesis

What is 1,3-Cyclohexanedione?

1,3-Cyclohexanedione (1,3-CHD) is a cyclic diketone with the chemical formula C6H8O2. It is commonly used as an intermediate in the synthesis of various organic compounds, particularly in the production of pharmaceuticals, agrochemicals, and specialty chemicals. Due to its reactivity, 1,3-CHD plays a crucial role in chemical synthesis and is known for its ability to undergo diverse chemical reactions, making it a versatile building block in industrial applications.

Chemical Properties and Structure

• Chemical Formula: C6H8O2

• Molecular Weight: 112.13 g/mol

• Appearance: 1,3-CHD is a colorless to pale yellow liquid with a characteristic odor.

• Melting Point: -10°C

• Boiling Point: 239°C

• Solubility: It is soluble in organic solvents such as ethanol, ether, and chloroform, but insoluble in water.

Applications of 1,3-Cyclohexanedione

1. Pharmaceuticals:

   • 1,3-CHD is used as an intermediate in the synthesis of various pharmaceutical compounds, including anti-inflammatory and antibacterial agents. It is also utilized in the development of enzyme inhibitors and drug candidates for treating cancer and other diseases.

   
   

2. Agrochemicals:

   • It serves as a key building block in the synthesis of herbicides and pesticides. Its reactivity allows it to be used in the preparation of chemicals that protect crops from weeds and pests.

   
   

3. Specialty Chemicals:

   • 1,3-CHD is involved in the production of polymer additives, flavoring agents, and dyes. It is used to create compounds with specific functional groups that enhance the performance of materials in various industries.

   
   

4. Organic Synthesis:

   • In organic chemistry, 1,3-CHD is used as a precursor for heterocyclic compounds and in the synthesis of complex molecules. It plays an important role in the creation of aromatic compounds and cyclic structures in research and industrial chemistry.

   
   

Key Reactions and Mechanisms

1. Michael Addition:

   • 1,3-CHD undergoes Michael addition reactions with various nucleophiles, forming adducts that are useful in synthesizing complex organic molecules.

   
   

2. Aldol Condensation:

   • It participates in aldol condensation reactions, forming β,β-unsaturated carbonyl compounds that are valuable intermediates in the synthesis of pharmaceuticals and agrochemicals.

   
   

3. Cyclization Reactions:

   • 1,3-CHD can undergo cyclization reactions to form heterocyclic compounds, which are important in the synthesis of medicinal compounds and functional materials.

   
   

4. Electrophilic Substitution:

   • It can also participate in electrophilic substitution reactions, such as halogenation and nitration, to introduce functional groups into the cyclohexane ring.

   
   

Benefits of 1,3-Cyclohexanedione

1. Versatile Intermediate:

   • 1,3-CHD’s ability to undergo a wide range of chemical reactions makes it a valuable intermediate in organic synthesis.

   
   

2. Wide Application Range:

   • Its applications span across multiple industries, including pharmaceuticals, agriculture, and specialty chemicals, highlighting its versatility.

   
   

3. Efficient Synthesis:

   • 1,3-CHD can be used to synthesize a variety of complex molecules in a cost-effective and efficient manner, making it an essential tool for industrial chemists and researchers.

   
   

4. High Reactivity:

   • The reactivity of 1,3-CHD allows it to be used in the preparation of high-value compounds with specific functional groups, enhancing the properties of final products.

   
   

Why Choose JIN DUN CHEMICAL’s 1,3-Cyclohexanedione?

At JIN DUN CHEMICAL, we provide high-quality 1,3-Cyclohexanedione that meets the stringent requirements of various industries.

• Superior Quality: Our 1,3-CHD is manufactured under controlled conditions, ensuring consistent quality and high purity in every batch.

• Competitive Pricing: We offer affordable pricing for 1,3-Cyclohexanedione, making it an ideal choice for businesses of all sizes.

• Global Standards: Our products comply with international standards, ensuring they meet regulatory requirements for use in pharmaceuticals, agrochemicals, and specialty chemicals.

Usage Recommendations

1. Dosage:

   • The dosage of 1,3-CHD depends on the specific application. In organic synthesis, it is typically used at concentrations ranging from 1% to 10% by weight, depending on the reaction.

   
   

2. Handling:

   • Handle 1,3-CHD with care in a well-ventilated area. Wear appropriate protective equipment, such as gloves and goggles, to avoid direct contact with the substance.

   
   

3. Storage:

   • Store 1,3-CHD in tightly sealed containers in a cool, dry place, away from heat and direct sunlight. It should be kept in a well-ventilated area to avoid the buildup of vapors.

   
   

Frequently Asked Questions (FAQ)

Q1: What are the primary uses of 1,3-Cyclohexanedione?
A1: 1,3-CHD is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It plays a key role in the production of herbicides, pesticides, and drug candidates.

Q2: Is 1,3-Cyclohexanedione safe to handle?
A2: 1,3-CHD should be handled with care. It is recommended to use appropriate protective equipment and work in a well-ventilated area to avoid direct exposure.

Q3: Can 1,3-Cyclohexanedione be used in drug synthesis?
A3: Yes, 1,3-CHD is widely used in the synthesis of pharmaceutical compounds, including anti-inflammatory and anticancer agents, due to its reactivity and versatility.

Q4: How does 1,3-Cyclohexanedione contribute to agrochemical production?
A4: 1,3-CHD is used as a building block in the synthesis of herbicides and pesticides, helping to protect crops from pests and weeds.

Partner with JIN DUN CHEMICAL for High-Quality 1,3-Cyclohexanedione

Choose JIN DUN CHEMICAL for reliable, high-performance 1,3-Cyclohexanedione. Whether you're in the pharmaceutical, agrochemical, or specialty chemical industry, our products deliver the results you need. Contact us today to learn more!