Introduction
N,N-Dimethylcapramide (DMCA) is a high-performance aprotic solvent known for its thermal stability, low volatility, and excellent solubilizing capacity. Widely used in pharmaceuticals, agrochemicals, and polymer chemistry, it offers advantages over traditional solvents like dimethylformamide (DMF) and dimethylacetamide (DMAc).
Chemical Name: N,N-Dimethylcapramide
CAS Number: 14433-76-2
Molecular Formula: C12H25NO
Molecular Weight: 199.33 g/mol
Appearance: Clear, colorless to pale yellow liquid
Boiling Point: ~280°C
Solubility: Miscible with most organic solvents
High Boiling Point: Ideal for high-temperature reactions
Excellent Solvent Power: Dissolves a wide range of organic and inorganic substances
Low Volatility: Reduces evaporation loss in long processes
Low Toxicity: Safer alternative to traditional amides like DMF
Industry | Application |
---|---|
Pharmaceuticals | Reaction medium for drug synthesis and crystallization |
Agrochemicals | Solvent for pesticide formulations |
Polymers & Plastics | Solvent in polymerization and spinning processes |
Electronics | Cleaning agent and solvent in specialty coatings |
Personal Protection: Use gloves, goggles, and lab coat
Storage Conditions: Store in a cool, dry, well-ventilated area away from heat sources
Stability: Chemically stable under normal conditions
Packaging: Typically supplied in HDPE drums or steel containers
✅ Safer than DMF and DMAc
✅ Minimal odor
✅ High thermal and chemical stability
✅ Compatible with a wide range of formulations
❌ Limited biodegradability—requires proper waste handling
❌ Not suitable for use in aqueous systems
❌ Availability may be limited compared to more common solvents
Q: How does DMCA compare to DMF or DMAc?
A: DMCA is less toxic and has a higher boiling point, making it preferable in high-temperature, long-duration applications.
Q: Is DMCA suitable for food or cosmetic use?
A: No, DMCA is intended for industrial applications only and is not approved for food-grade or cosmetic uses.
Q: What types of substances can it dissolve?
A: It dissolves a wide range of resins, polymers, agrochemicals, and pharmaceutical intermediates.
Conclusion
N,N-Dimethylcapramide is a powerful and safer solvent alternative for industries that demand high thermal resistance and broad solubility. With its superior performance and lower toxicity, it plays a crucial role in modern specialty chemical formulations.